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T John Martin Selected Research

Parathyroid Hormone-Related Protein

10/2021Dmp1Cre-directed knockdown of parathyroid hormone-related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny.
1/2021Multiple actions of parathyroid hormone-related protein in breast cancer bone metastasis.
1/2021PTH1R Actions on Bone Using the cAMP/Protein Kinase A Pathway.
11/2019Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism.
1/2018Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner.
1/2018Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein.
1/2016Parathyroid Hormone-Related Protein, Its Regulation of Cartilage and Bone Development, and Role in Treating Bone Diseases.
10/2014PTHrP, its receptor, and protein kinase A activation in osteosarcoma.
6/2012Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine.
5/2011Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma.
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T John Martin Research Topics

Disease

15Neoplasms (Cancer)
01/2021 - 02/2002
12Bone Resorption
01/2021 - 11/2003
8Osteoporosis
01/2018 - 09/2005
6Neoplasm Metastasis (Metastasis)
01/2021 - 02/2006
6Breast Neoplasms (Breast Cancer)
01/2021 - 02/2006
6Bone Diseases (Bone Disease)
01/2016 - 12/2007
4Osteosarcoma (Osteogenic Sarcoma)
04/2015 - 08/2008
4Inflammation (Inflammations)
08/2014 - 07/2004
3Metabolic Bone Diseases (Osteopenia)
10/2021 - 02/2004
3Humoral Hypercalcemia Of Malignancy
11/2019 - 02/2002
3Hypercalcemia (Milk Alkali Syndrome)
06/2012 - 05/2011
2Carcinoma (Carcinomatosis)
01/2018 - 11/2003
2Osteolysis
04/2006 - 11/2003
2Experimental Arthritis
07/2004 - 10/2002
1Hypertrophy
04/2021
1Infections
11/2014
1Arthritis (Polyarthritis)
08/2014
1Anemia
05/2011
1Mesoblastic Nephroma (Congenital Mesoblastic Nephroma)
05/2011
1Insulin Resistance
07/2009
1Disease Susceptibility (Diathesis)
10/2008
1Neurofibromatosis 1 (Neurofibromatosis Type I)
12/2006
1Inborn Genetic Diseases (Disease, Hereditary)
12/2006
1Chondrosarcoma
04/2002
1Chondroma (Enchondroma)
04/2002
1Osteochondroma (Osteocartilaginous Exostosis)
04/2002

Drug/Important Bio-Agent (IBA)

19Parathyroid Hormone-Related ProteinIBA
10/2021 - 02/2002
6Proteins (Proteins, Gene)FDA Link
01/2021 - 02/2002
6Parathyroid Hormone (Parathormone)IBA
11/2019 - 03/2004
4Hormones (Hormone)IBA
01/2021 - 06/2010
4OsteoprotegerinIBA
02/2007 - 10/2002
3CytokinesIBA
08/2014 - 01/2011
2Interleukin-6 (Interleukin 6)IBA
10/2019 - 02/2004
2Messenger RNA (mRNA)IBA
01/2018 - 11/2014
2Pharmaceutical PreparationsIBA
06/2015 - 02/2010
2Type 1 Parathyroid Hormone Receptor (Parathyroid Hormone Receptor)IBA
10/2014 - 04/2002
2Neutralizing AntibodiesIBA
06/2009 - 02/2007
1FollistatinIBA
04/2021
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2021
1A-factor (Streptomyces)IBA
01/2021
1Adenylyl Cyclases (Adenylyl Cyclase)IBA
01/2021
1abaloparatideIBA
01/2018
1amino-terminal parathyroid hormoneIBA
01/2018
1Cyclic AMP (AMP, Cyclic)IBA
01/2018
1Coloring Agents (Dyes)IBA
01/2018
1Teriparatide (Parathar)FDA Link
01/2018
1RetinoidsIBA
01/2016
1RecQ HelicasesIBA
04/2015
1Complement System Proteins (Complement)IBA
10/2014
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
10/2014
1Oncostatin MIBA
08/2014
1AntigensIBA
08/2014
1Anabolic AgentsIBA
06/2014
1Small Interfering RNA (siRNA)IBA
07/2013
1ErythropoietinFDA Link
05/2011
1Calcitriol (Calcijex)FDA LinkGeneric
05/2011
1Pamidronate (Aredia)FDA LinkGeneric
05/2011
1Furosemide (Lasix)FDA LinkGeneric
05/2011
1MineralsIBA
05/2011
1Calcitonin (Calcitonin, Eel)FDA LinkGeneric
05/2011
1CalciumIBA
05/2011
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2011
1ProgesteroneFDA LinkGeneric
06/2010
1LigandsIBA
01/2010
1Biological ProductsIBA
01/2010
1Insulin (Novolin)FDA Link
07/2009
1OsteocalcinIBA
07/2009
1Glucose (Dextrose)FDA LinkGeneric
07/2009
1Chemotactic FactorsIBA
05/2009
1Interleukin-23 (Interleukin 23)IBA
10/2008
1RNA (Ribonucleic Acid)IBA
08/2008
1Estrogens (Estrogen)FDA Link
09/2007
1Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA
02/2007
1RANK LigandIBA
02/2007
1Activating Transcription Factor 4IBA
12/2006
1Dietary ProteinsIBA
12/2006
1Progesterone Receptors (Progesterone Receptor)IBA
02/2006
1Estrogen ReceptorsIBA
02/2006
1Zoledronic Acid (Zometa)FDA Link
07/2004
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
04/2004
1Diphosphonates (Bisphosphonates)IBA
11/2003
1Transforming Growth Factor beta1 (TGF beta 1)IBA
11/2003

Therapy/Procedure

10Therapeutics
01/2018 - 12/2006
1Intramuscular Injections
04/2021
1Chemoprevention
06/2010
1Fracture Fixation
01/2007